Effect of Ambroxol on Secretion, Production and Gene Expres- sion of Mucin from Cultured Airway Epithelial Cells
نویسندگان
چکیده
pharmacological means to inhibit mucin secretion and/or production has become an important approach to regulate the hypersecretion of airway mucus (Mutschler and Derendorf, 1995). Secretion of airway mucin is generally stimulated by various agents. Whereas glucocorticoids inhibit the hypersecretion of airway mucins (Mutschler and Derendorf, 1995; Lee et al., 2002), they have various limitations in their application to pharmacotherapy of human diseases involving airway mucus hypersecretion. An alternative approach for regulation of airway mucus hypersecretion is to inhibit the excessive mucin secretion and/or production using agents that have already been clinically used for the management of various diseases. According to a number of studies, ambroxol one of the clinically-used mucolytics and/or expectorants was reported to demonstrate anti-oxidative and/or anti-infl ammatory activity (Stetinova et al., 2004; Beeh et al., 2008). Ambroxol increased the secretion of pulmonary surfactant which is involved in the expectorant action of ambroxol (Miyata et al., 1986). Ambroxol provoked serous and mucous secretion and restored normal production of mucin in patients suffering from chronic bronOriginal Article Biomol Ther 19(1), 65-69 (2011)
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